Inhibitors of DNA Methyltransferases From Natural Sources: A Computational Perspective
نویسندگان
چکیده
منابع مشابه
Bacterial efflux pump inhibitors from natural sources.
The rapid spread of bacteria expressing multidrug resistance (MDR) has necessitated the discovery of new antibacterials and resistance-modifying agents. Since the initial discovery of bacterial efflux pumps in the 1980s, many have been characterized in community- and hospital-acquired Gram-positive and Gram-negative pathogens, such as Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia c...
متن کاملA computational study to identify potential inhibitors for human chymase from natural and/or biogenic sources
Motivation The human chymase (EC 3.4.21.39) is a hydrolase abundant in secretory granules of mast cells, responsible for the synthesis of angiotensin II from its precursor. Moreover, it is also responsible for the conversion of transforming growth factor-β (TGF-β) and matrix metalloproteinase (MMP)-9 precursors to their active forms. Since a link between heart failure and chymase has been prove...
متن کاملDietary Flavones as Dual Inhibitors of DNA Methyltransferases and Histone Methyltransferases
Methylation of DNA and histone proteins are mutually involved in the epigenetic regulation of gene expression mediated by DNA methyltransferases (DNMTs) and histone methyltransferases (HMTs). DNMTs methylate cytosine residues within gene promoters, whereas HMTs catalyze the transfer of methyl groups to lysine and arginine residues of histone proteins, thus causing chromatin condensation and tra...
متن کاملCorrection: Dietary Flavones as Dual Inhibitors of DNA Methyltransferases and Histone Methyltransferases
[This corrects the article DOI: 10.1371/journal.pone.0162956.].
متن کاملSelective Inhibitors of Protein Methyltransferases
Mounting evidence suggests that protein methyltransferases (PMTs), which catalyze methylation of histone and nonhistone proteins, play a crucial role in diverse biological processes and human diseases. In particular, PMTs have been recognized as major players in regulating gene expression and chromatin state. PMTs are divided into two categories: protein lysine methyltransferases (PKMTs) and pr...
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ژورنال
عنوان ژورنال: Frontiers in Pharmacology
سال: 2018
ISSN: 1663-9812
DOI: 10.3389/fphar.2018.01144